Evaluation of Ayurvedic oil Jathyadi thailam used for chronic wound healing
Dr. Tatjana Tracevska
Emerging bacterial resistance in response to antimicrobial therapy is a world-wide problem nowadays, stimulating the search for new antimicrobial compounds. The aim of this study was to initiate an effective collaboration between academic research and industrial partner, involving specialists in Ayurveda, to explore the efficacy of the traditional Ayurvedic formulation and its modifications.
The object of present study is a polyherbal formulation, Jathyadi Thailam, based on 13 herbs infusion in coconut oil, used in Ayurvedic medicine for chronic wound (e.g. Diabetic foot ulcers) and burns healing, according to AVP formulation. Preliminary results indicated the need for modification of Jathyadi Thailam for further studies in vitro. The extracts of formulation were obtained using the reverse pharmacology method and processed further for microbiological and cellular studies in vitro.
The AVP formulation was effective against Staphyloccus aureus, including methicillin resistant staphylococci, the bacteria predominantly found in chronic diabetic wounds. In general, both herbal crude extracts and the final herbal oil were found to be more effective for Gram positive bacteria, when for Gram negative. AVP fractions showed anti-inflammatory properties in human cell lines. Further studies will be focused on development of herbal suspension with better skin penetrating properties.
Funding: The study was funded from LU effective collaboration project No ZD2016/20226 and Arya Vaidya Chikitsalayam and Research Institute.